Exploring the Potential for a Guinea Pig model to Study Human Muscle Aging

Researchers find promising model to study human aging

Fans of aging research may enjoy this.

Hamiliton’s team discovered that the Dunkin Hartley guinea pig is a good candidate as a muscle aging models due to its tendency to develop osteoarthritis at a young.

Mental and physical aging have many different components. When it comes to the infrastructure of the human body–the musculoskeletal system that includes muscles, bones, tendons and cartilage–age-associated decline is inevitable, and the rate of that decline increases the older we get. Sarcopenia and dynapenia are scientific terms for the loss of muscle mass and function.

Sarcopenia in adults over 40 is not noticeable. About 3% of muscle mass is lost every decade. Muscle decline is more rapid in those 65 and older. They lose an average of 1% each year. Sarcopenia is also characterized by decreased strength, an impaired gait, a reduced level of physical activity or difficulty with everyday tasks.

Research into the process of musculoskeletal degeneration is being driven by the projected more than two-fold increase in older adults over 65 years old. Researchers at Colorado State University’s Columbine Health Systems Center for Healthy Aging are confident that they have discovered an animal model which will help them to better understand the condition and find ways of reducing its symptoms.



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